Dr. Cubillos-Ruiz is an Assistant Professor of Microbiology and Immunology in the department of Obstetrics and Gynecology and the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine in New York.
Harnessing the intrinsic ability of our immune system to eliminate malignant cells represents the most promising anti-cancer strategy since the development of chemotherapy. Immunotherapy is shifting the face of cancer treatment, but adverse microenvironmental conditions within ovarian tumors inhibit the protective activity of immune cells and thus represent an impediment to the success of this approach. New and more effective strategies are urgently needed in the clinic to re-arm the immune system against ovarian cancer. We have discovered that immune cells in ovarian cancer are “stressed out” due to adverse factors and conditions that these tumors can produce. Our project’s central hypothesis is that stressed out immune cells inside the ovarian tumor are unable to execute their protective functions. To prove this, we will determine how ovarian cancer induces cellular stress in the immune system, and test whether disabling “stress sensors” in immune cells could be used as a novel immunotherapeutic approach for ovarian cancer.
The Jacquie Liggett Ovarian Cancer Research Fellowship has been established for basic or translational research conducted in the United States with priority given to Florida. The Fellow can either be a Doctor of Medicine or a PhD.
The award will be given for $50,000 per year and the term of the Fellow's grant will generally be for two years with the possibility of a third year at the recommendation of the H.O.W. Medical Advisory Board.
If the Fellow presents at a recognized society, HOW will contribute $2,000 toward the expenses in addition. Every effort is to be made that the Fellow's primary location for research or for conducting business remains in Florida.
Candidates must submit the following by email to the Chairman of the H.O.W. Medical Advisory Board, Robert C. Knapp, M.D. at email@example.com and Jennifer McGrath, H.O.W.'s director at Jennifer@howflorida.org. For questions, please call (561) 406-2109.